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Benzalkonium Chloride

Specializing in the production of pharmaceutical excipients

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Benzalkonium Chloride

(CDMF NO.: F20209990126)

Name:Benzalkonium Chloride

  • F.:[C6H5CH2N(CH3)2R]Cl

M.W.360(Average value)

CAS No.8001-54-5

Package: 0.5kg/bottle*12 /carton; 0.8kg/bottle*24 /carton;

 R = hydrocarbon mixture from n-C18H17 to n-C18H37 

mainly n-C12H25, n-C14H29, n-C16H33


White waxy solid or yellow colloid; its aqueous solution is neutral or weakly alkaline, and a large amount of foam is generated when shaking. Easily soluble in water or ethanol, slightly soluble in ether.

Quality Standard: CHP 2020; USP40-NF35; EP9.0

C12 NLT 40.0%; C14 NLT 20.0%; C12+C14 NLT 70.0%


It is a cationic surfactant of the quaternary ammonium salts.

As preservatives, widely used in ophthalmic preparations, but also in nasal and ear preparations, small volume injections and cosmetics.

ApplicationDosage/ %Examples
 Ophthalmic preparation0.01% -0.02%Lysozyme eye lotion
Nasal and ear preparation 0.002% -0.02%   
Small volume injection  0.01%Hydrocortisone phosphate injection


This product is incompatible with aluminum, anionic surfactants, citrate, cotton, fluorescein, hydrogen peroxide, hypromellose, iodide, kaolin, lanolin, nitrate, and high-concentration nonionic surfactants, permanganic acid, protein, salicylate, silver salt, soap, sulfa drugs, zinc oxide, zinc sulfate, some rubber mixtures and some plastic mixtures.


This dilute solution is usually non-irritating, non-allergenic and easily tolerated in transdermal and mucosal preparations.


It has hygroscopicity. Light, air and metal affect its stability.

Stored in sealed container in a cool, dry and dark place, and avoid contact with metal.

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