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Medium-chain Triglycerides

Specializing in the production of pharmaceutical excipients

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Medium-chain Triglycerides

( NMPA CDE NO.: F20220000316)

Name: Medium-chain Triglycerides NF/ Triglycerides medium-chain EP /

Medium chain fatty acid triglyceride JPE.

Other names: Capryic/Capric Triglyceride

CAS No.: 73398-61-5(or 85409-09-2) (or  538-24-9)

Package: 5kg/bottle*4bottles/carton, 20kg/carton


This product is a colorless or light yellow oily liquid, odorless, tasteless, freezing point is about 0℃.

It can be miscible with methylene chloride, petroleum ether, or soybean oil. It is easily soluble in methanol and almost insoluble in water.

Quality Standard: CP2020; USP43-NF38;  In-house specification


This product is made from the hard and dry part of the endosperm of coconut Cocos nucifera L, or the dry part of the endosperm of oil palm Elaeis guineensis Jacq. The saturated fatty acids such as capic acid (C8H16O2) and capric acid (C10H20O2) are separated from the fat oil.

A mixture of triglycerides produced by esterification with triglycerides. The total amount of Caprylic acid (C8H16O2) and Decric acid (C10H20O2) shall not be less than 95.0%.


1. Good solvent for fat-soluble drugs, and is not easy to oxidize, good compatibility with drugs.

2. Better spreading performance on the skin does not affect the skin breathability;

3. Good skin moisturizing effect, promote the penetration and release of drugs;

4. High-quality raw materials and excellent refining process, the product is colorless and transparent, stable and reliable quality.


In oral preparations, Medium-chain Triglycerides are used as a substrate for the preparation of oral emulsions, microemulsions, self-emulsifying systems, solutions, or suspensions of drugs in unstable or insoluble media, such as alfacalcalcitol. MTG can also be used as an intestinal absorption promoter or as a lubricant or anti-stick agent in common tablets.

In topical pharmaceutical preparations, medium-chain triglycerides can be used as oil-soluble substrates for ointments, creams, and liquid emulsions

Incompatibility: /


Storage:  Preserve in airtight containers in a cool and dry place.

ItemsIn-house specification 
CharacterColorless to slightly yellow clear oil liquid.Miscible with methylene chloride, petroleum ether or soybean oil, easily soluble in methanol, almost insoluble in water.
Refractive index1.440~1.452(20℃)
Relative density0.93~0.96(20℃)
Viscosity 25~33 mPa·s(20℃)
Acid value≤0.2
Hydroxyl value≤10
Iodine value≤1.0
Peroxide value≤1.0
Saponification value310~360
IdentificationIn the chromatograms recorded under fatty acid composition, the retention times of methyl octanoate peak and methyl capric acid peak in the test solution should be consistent with those of the corresponding peaks in the control solution.
Clarity and colorThis product should be clear and colorless; Such as color, compared with yellow No. 3 standard colorimetric solution, not deeper.
Unsaponifiable matter≤0.5%
Alkaline impuritiesNMT 0.15 mL of (0.01mol/L ) hydrochloric acid  is required.
Water content≤0.2%
Residue on ignition≤0.1%
Heavy metalsNMT 10ppm
Composition of
fatty acid
Octylic acid: 50.0~80.0%
Hexylic acid: ≤2.0%
Decylic acid: 20.0~50.0%
Lauric acid: ≤3.0%
Myristic acid: ≤1.0%
Fatty acids greater than or equal to 16 carbon: ≤1.0%
Microbial limitOctylic acid and Decylic acid: ≥95.0%

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