Sodium Stearyl Fumarate
(F20190000009)
名称： 硬脂富马酸钠
CAS No.: 4070-80-8
Package: 1kg/bag, 5kg/carton, 20kg/drum.
Appearance:
White to off-white powder or granule.
Almost insoluble in water, slightly soluble in methanol, insoluble in acetone and anhydrous ethanol.
Quality Standard: CP2020; USP2023; EP11.0.
Application:
*As lubricants for tablets and capsules with a concentration of 0.5 ~ 2.0% (w/w).
*It can form a protective coat film in effervescent tablets.
As this product has one fatty chain less and one hydrophilic group more compared with magnesium stearate, so it can solve the slow dissolution of magnesium stearate as lubricant.
*Suitable for lubricants of razole drugs, which are easy to react with magnesium stearate and cannot use magnesium stearate as lubricant.
*As a regulator and stabilizer, such as baked foods, floured thickened foods, baked potatoes and processed grains, with dosage for 0.2 %~ 1.0% of the food weight.
| Application | Examples | Concentration |
| Lubricants for tablets and capsules | Levofloxacin tablets;Sitagliptin phosphate and metforminhydrochloride sustained-release tablets;Oseltamivir phosphate capsules Ramipril tabletsMorapiravirAildenafil citrate tabletsFluvoxamine maleate tablets(combinedwith stearic acid） | 0.5% ~ 3.0% |
| A protective coat film in effervescent tablet | Vitamin C effervescent tablets |
Benefits:
·Improved drug stability
· Shorter disintegration times
. Faster dissolution rates
. Enhanced lubrication efficiency
. Harder tablets in comparison to tablets produced with magnesium stearate
· Faster formulation development and scale-up
Incompatibility: Incompatible with chlorhexidine acetate.
Safety: Generally considered non-toxic and non-irritating.
Storage: Preserve in well-closed containers.