Polyethylene Glycol 300(for Injection)
(CDE REGISTRATION NO.: F20250000194)
Name: Polyethylene glycol 300 (for injection)
CAS No.: 25322-68-3
Other name: PEG-300
Molecular formula: H(OCH2CH2)nOH，n=the average number of oxyvinyl groups.
Average molecular weight: 285-315
Quality Standard: USP-NF, EP, ChP2025
Packaging: 0.5kg/bottle; 1kg/bottle/carton; 5kg/bottle/carton; 20kg/bottle/ca rton
Appearance: A colorless or nearly colorless viscous liquid
Solubility: Readily soluble in water or ethanol.
Structure:
Application：
| Application | Function | Advantage | Sample |
| Pharm grade | Solvent / Solubilizer | Improve the solubility of poorly soluble drugs-Chemically stable, safe, and low-toxic. | |
| Injection grade | Carrier and stabilizer | Inhibits aggregation of biologics (e.g., 0.5–2% PEG300suppresses rhKGFaggregation).-Reduces hydrolysis of labile drugs. | Mesobamo Injection |
| Drug delivery systems /Controlled releaseand targeted delivery | Carrier | Optimizes drug releasekinetics, reducing dosingfrequency.- Enhances targeting and therapeutic efficacy.Increases drug solubility and in vivo circulation time. |
Incompatibility
1. There is a risk of reaction with strong oxidizing agents, as the ether bonds and hydroxyl groups in its molecular structure readily react with oxidants.
2. It has a swelling or dissolving effect on plastics such as polyethylene, polyvinyl chloride, and phenolic resins, as well as cellulose ester filter membranes, which may affect the integrity of packaging containers or filtration systems.
Satety
Approved by the FDA for injectable use, it exhibits low toxicity and low immunogenicity, with no toxic reactions observed at final concentrations up to 50% (v/v) administered intravenously or intramuscularly.
Storage
Store in a cool, dry, and well-ventilated place, sealed, at an ambient temperature not exceeding 40°C. Avoid contact with humid air and oxidants.The prepared solution must be sealed and protected from light. It can be stored for 1 month at -20 °C and 6 months at -80°C. Repeated freeze-thaw cycles will cause the solution to lose its effectiveness; it is recommended to aliquot and use only as needed.