Tagatose
( NMPA CDE NO.: F20250000137)
Name: Tagatose
M. F.: C6H12O6
M.W.: 180.16
CAS No.: 87-81-0
Packaging:1kg/bag/carton; 5kg/bag/carton; 20kg/bag/drum
Quality Standard: USP-NF
Appearance: White or almost white crystals, having a sweet taste.
Very soluble in water; very slightly soluble in alcohol. NF category: Sweetening agent; humectant.
Definition
Tagatose is a ketohexose, an epimer of d-fructose inverted at C-4. It is obtained from d-galactose by isomerization under alkaline conditions in the presence of calcium. It contains NLT 98.0% of tagatose (C H O ), calculated on the dried basis.
Application:
| Application | Example |
| Flavoring agent | Oral liquid and syrup, orally disintegrating tablet, chewable tablet |
| Fillers/Diluents | Tablets, Capsules |
| Stabilizers and carriers | Lyophilized formulations, amorphous solid dispersions |
| Osmotic pressure enhancer | Osmotic pump tablet, controlled release preparations |
Advantage:
High safety, FDA has approved it as GRAS (Generally Recognized as Safe) substance.
Patient-friendly, suitable for diabetes patients, obese individuals, and children, improving medication adherence.
Natural source, in line with current market demand for natural ingredients.
For poorly soluble drugs, tagatose can serve as a carrier, and through techniques such as hot-melt extrusion and spray drying, the drug can be highly dispersed in an amorphous form within the tagatose matrix, thereby significantly enhancing the drug’s solubility and oral bioavailability.