Factory Address:Penggao, Shangli County, Pingxiang City, P.R.China
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Crospovidone

Specializing in the production of pharmaceutical excipients

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Crospovidone

Crospovidone.
PVPP AG0101 TYPE A
PVPP AG0102 TYPE B
Crospovidone

Name: Crospovidone (F20180000011)

Other Names: Cross-linked polyvinylpyrrolidone, PVPP

M.F.: (C6H9NO)n

M.W.: >1 000 000

CAS No.9003-39-8

Appearance: White or off-white powder; almost odorless; it’s hygroscopic.

Insoluble in water, ethanol, chloroform or ether.

Alpha PVPP is available in two particle size to serve different application requirement.

ProductsTypeTypical AverageParticle Size (μm)
PVPP AG0101Type A110-130
PVPP AG0102Type B20-40
PVPP Type
Crospovidone.
PVPP AG0101 TYPE A
PVPP AG0102 TYPE B
Crospovidone

Application: 

Crospovidone is mainly used as a disintegrating agent for tablets, pills, granules, and hard capsules. It can be used in wet granulation, dry granulation and direct powder tabletting at a concentration of 2% -5%.  It has good compressibility, can improve the stability, hardness, and friability of tablets, reduce chipping, and increase the tabletting pressure. It will only increase the tablet hardness without affecting the disintegration time. The disintegration performance of it is not affected by pH. At the same dosage, the disintegration speed is usually faster than starch, modified starch, croscarmellose sodium and methyl cellulose.

In addition, this product can also be used as a solubilizer for poorly soluble drugs, a solid dispersion carrier for immediate release drugs, and a swelling layer material for pulse preparations.

Application Examples:

Highly effective disintegrant (commonly used in dispersible tablets):

Amoxicillin Dispersible Tablets

Poorly soluble drug solubilizer:               

Telmisartan Dispersible Tablets

Solid dispersion carrier:                     

Cilostazol solid dispersible tablets

Other swelling materials such as pulse preparations

Packaging:

Crospovidone is known to form peroxides upon prolonged exposure to oxygen, and  has strong hygroscopicity. As our commitment to ensure the quality and stability, our Crospovidone is packaged in 20kg drum with double layer low density polyethylene bag.

1kg/bag, 5kg/bag, 20kg/drum.

Storage:

Crospovidone has strong hygroscopicity and should be stored in air-tight containers in a cool and dry place.

Sample size:

50 g free sample

Regulatory Information

Conforms to the current CP,USP/NF,EP.

BES/TSE Free

CDMF- letter of authorization is available upon request

Conforms to the Residual Solvents requirement of Ph. Eur. (5.4) and USP <467>.

Elemental Impurity Statement available

GMO Free

GMP Statement available

Halal and Kosher compliant

Non-Animal Origin

OVI Free

Stability Test Report

 

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