Crospovidone
Name: Crospovidone (F20180000011)
Other Names: Cross-linked polyvinylpyrrolidone, PVPP
M.F.: (C6H9NO)n
M.W.: >1 000 000
CAS No.：9003-39-8
Appearance: White or off-white powder; almost odorless; it’s hygroscopic.
Insoluble in water, ethanol, chloroform or ether.
Quality standard: CP2020; USP43-NF38; EP10.0
Product Code& Key index:
| Products | Hydratability | Bulk Density | Typical Average Particle Size (μm) | |||
| Alpha (CL-F) | 5-6.6 | 0.18-0.28 | 20-40 | Type B | ||
| Alpha (CL) | 3.5-5.5 | 0.3-0.4 | 110-130 | Type A | ||
| Alpha (XL-10) | 4.5-5.5 | 0.3-0.4 | 25-40 | |||
| Alpha (XL) | 5.5-6.5 | 0.3-0.4 | 110-140 | |||
| Alpha (X) | Customized |
Application:
Crospovidone is mainly used as a disintegrating agent for tablets, pills, granules, and hard capsules. It can be used in wet granulation, dry granulation and direct powder tabletting at a concentration of 2% -5%. It has good compressibility, can improve the stability, hardness, and friability of tablets, reduce chipping, and increase the tabletting pressure. It will only increase the tablet hardness without affecting the disintegration time. The disintegration performance of it is not affected by pH. At the same dosage, the disintegration speed is usually faster than starch, modified starch, croscarmellose sodium and methyl cellulose.
In addition, this product can also be used as a solubilizer for poorly soluble drugs, a solid dispersion carrier for immediate release drugs, and a swelling layer material for pulse preparations.
Application Examples:
Highly effective disintegrant (commonly used in dispersible tablets):
Amoxicillin Dispersible Tablets
Poorly soluble drug solubilizer:
Telmisartan Dispersible Tablets
Solid dispersion carrier:
Cilostazol solid dispersible tablets
Other swelling materials such as pulse preparations
Packaging：
Crospovidone is known to form peroxides upon prolonged exposure to oxygen, and has strong hygroscopicity. As our commitment to ensure the quality and stability, our Crospovidone is packaged in 20kg drum with double layer low density polyethylene bag.
1kg/bag, 5kg/bag, 20kg/drum.
Storage：
Crospovidone has strong hygroscopicity and should be stored in air-tight containers in a cool and dry place.
Sample size：
50 g-200g free sample
Regulatory Information
Conforms to the current CP,USP/NF,EP.
BES/TSE Free
CDMF- letter of authorization is available upon request
Conforms to the Residual Solvents requirement of Ph. Eur. (5.4) and USP <467>.
Elemental Impurity Statement available
GMO Free
GMP Statement available
Halal and Kosher compliant
Non-Animal Origin
OVI Free
Stability Test Report