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Oleyl Alcohol

Specializing in the production of pharmaceutical excipients

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Oleyl Alcohol

Name: Oleyl Alcohol

M.F.: C18H36O

M.W.: 268.5

CAS No.: 143-28-2

Packaging: 5kg/bottle*2bottles/carton; 5kg/bottle*4bottles/carton

Quality Standard: USP43-NF38; EP10.0;BP.

Appearance: Colorless to pale yellow clear oily liquid with a faint special odor and a plain taste.

It is soluble in ethanol, ether, isopropanol and light mineral oil, insoluble in water.

Application: 

A mixture of saturated and unsaturated long-chain fatty alcohols. The HLB value is 14, making it a widely used surfactant.

Oleyl Alcoho is a highly purified lipid-based solubiliser and skin penetration enhancer that acts as a wetting agent and active dispersant in topical creams and ointment applications.

Oleyl Alcoho is a lipophilic enhancer that promotes skin penetration by means of bilayer disruption and disordering. It assists the percutaneous absorption of water-soluble and oil-soluble drugs by means of partial leaching of the epidermal lipids. The bilayer architecture of the stratum corneum lipids is disorganised by the introduction of phase separation and direct disruption of a proper lamellar arrangement. This results in the improvement of the skin’s reception for transdermal and transfollicular penetration. The proprietary Super Refining process removes impurities without altering the chemical composition of the excipient. This reduces the potential for adverse interactions between the excipient and the API, enhancing active stability and efficacy.

ApplicationFunctionExample
PatchMoisturizing agentPenetrating agentOil phase matrix 
CosmeticCream, lotion, gel
OintmentPyrrolimus Cream 1%:Each gram of 1% ELIDEL cream contains 10 mg of Pyrrolimus, with a white cream base consisting of benzyl alcohol, cetyl alcohol, citric acid, monoglycerides and diglycerides, oleyl alcohol, propylene glycol, sodium cetyl sulfate, sodium hydroxide, stearyl alcohol, triglycerides, and water.

Incompatibility: Incompatible with strong acids and oxidants. It can dissolve some rubbers and swell them.

Safety: This product has low toxicity but should not be taken orally, and has a slight tissue irritation.

Storage: This product should be preserve in well-filled, tight containers, and store at controlled room temperature.